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Herbs & Supplements > Herbs > Andrographis paniculata Nees, Kan Jang®, SHA-10

Overview

Andrographis paniculata Nees, Kan Jang®, SHA-10

The leaves of Andrographis paniculata have been as part of Indian folk medicine and Ayurveda for centuries. The Chinese and Thai herbal medicine systems have also used this herb, mostly for its "bitter" properties, as a treatment for digestive problems and for a variety of fever-causing illnesses. More recently, this herb has become popular in Scandinavia as a remedy for upper respiratory infections (URIs) and the flu.

The most widely tested product is a product called Kan Jang® (Swedish Herbal Institute). This product is available with andrographis alone and in combination with Eleutherococcus senticosus.

There is reasonably strong evidence from clinical trials to suggest that andrographis effectively reduces the severity and the duration of URIs. Based on animal and laboratory studies, andrographis may have a number of other potential therapeutic uses, including as an anti-inflammatory agent and as a treatment for chemically-induced liver damage. It has also been studied in human clinical trials for the flu and familial Mediterranean fever.

Interactions

Interactions with Drugs

Andrographis may increase the risk of bleeding. Use cautiously in patients taking anticoagulant agents, such as warfarin (Coumadin®) or heparin or with anti-platelet agents such as ibuprofen (Motrin®, Advil®) or clopidogrel (Plavix®). Andrographis use should be stopped before some surgeries; discuss this with a healthcare professional.

Andrographis may lower blood pressure and may therefore, add to the effects of drugs taken to lower blood pressure. Patients with high or low blood pressure who are considering taking any of these agents should discuss options with their healthcare professionals. Dosing adjustments may be necessary.

Andrographis may decrease blood sugar and may add to the effects of drugs taken to lower blood sugar, including insulin. Patients should be closely monitored by their healthcare professionals because dosing adjustments may be necessary.

Andrographis may also interact with allergy, anti-inflammatory, anti-cancer, antiviral, fertility, and immunomodulatory drugs.

Interactions with Herbs and Dietary Supplements

Andrographis may increase the risk of bleeding. Use cautiously in patients taking anticoagulant agents. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

In theory, andrographis may lower blood pressure and may therefore, add to the effects of agents that also lower blood pressure. Patients with high or low blood pressure who are considering taking any of these agents should discuss options with their healthcare professionals.

Andrographis may lower blood sugar. Patients taking other herbs or supplements that may affect blood sugar levels, such as bitter melon (Momordica charantia), should be monitored closely by a healthcare professional while taking andrographis.

Andrographis may also interact with anti-inflammatory, anti-cancer, antiviral, immunomodulatory, and fertility herbs and supplements.

Bibliography

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Amaryan G, Astvatsatryan V, Gabrielyan E, et al. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever. Phytomedicine 2003;10(4):271-285. View Abstract

Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 2000;14(5):333-338. View Abstract

Carr RR, Nahata MC. Complementary and alternative medicine for upper-respiratory-tract infection in children. Am J Health Syst.Pharm 1-1-2006;63(1):33-39. View Abstract

Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70(4):293-298. View Abstract

Dua VK, Ojha VP, Roy R, et al. Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata. J Ethnopharmacol 2004;95(2-3):247-251. View Abstract

Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9(7):589-597. View Abstract

Iruretagoyena MI, Tobar JA, Gonzalez PA, et al. Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse. J Pharmacol Exp Ther 2005;312(1):366-372. View Abstract

Kligler B, Ulbricht C, Basch E, et al. Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the natural standard research collaboration. Explore (NY) 2006 Jan;2(1):25-9. View Abstract

Kulichenko LL, Kireyeva LV, Malyshkina EN, et al. A randomized, controlled study of Kan Jang versus amantadine in the treatment of influenza in Volgograd. J Herb Pharmacother 2003;3(1):77-93. View Abstract

Kumar RA, Sridevi K, Kumar NV, et al. Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol 2004;92(2-3):291-295. View Abstract

Mandal SC, Dhara AK, Maiti BC. Studies on psychopharmacological activity of Andrographis paniculata extract. Phytother Res 2001;15(3):253-256. View Abstract

Melchior J, Spasov AA., Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated upper-respiratory tract infection. Phytomedicine 2000;7(5):341-350. View Abstract

Panossian A, Davtyan T, Gukassyan N, et al. Effect of andrographolide and Kan Jang--fixed combination of extract SHA-10 and extract SHE-3--on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture. Phytomedicine 2002;9(7):598-605. View Abstract

Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29(1):37-45. View Abstract

Spasov AA, Ostrovskij OV, Chernikov MV, et al. Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Phytother Res 2004;18(1):47-53. View Abstract

Related Terms

Andrographolide, Chuan Xin Lin, Green chiretta, Kalmegh leaf extract, Kan Jang®, King of Bitters, Kold Kare®, Remdex®.

Natural Standard Bottom Line Monograph, Copyright © 2009 (www.naturalstandard.com). Commercial distribution prohibited. This monograph is intendedfor informational purposes only, and should not be interpreted as specific medical advice. You should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Natural Standard's methodology , editorial board , and grading scales.

While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.

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Health Glossary

Andrographis paniculata Nees, Kan Jang®, SHA-10

Background

Evidence Table (Click Here to view Natural Standard evidence-based validated grading rationale™.)

Tradition

Tradition Theory

Dosing

Safety

Interactions

Attribution

Bibliography

Related Terms