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Gingival fibromatosis and hypertrichosis
Gingival fibromatosis and hypertrichosis (GFH) is a form of ectodermal dysplasia, one of a group of syndromes deriving from abnormalities of the ectodermal structures, which include the hair, teeth, nails, sweat glands, cranial-facial structure, and hands. These genetic disorders can be inherited in an autosomal dominant or recessive manner.GFH is a rare inherited genetic disorder that is passed down among family members. It follows an autosomal dominant pattern of inheritance, meaning that only one copy of the defective gene is needed for the condition to appear. There are some reports of autosomal recessive inheritance, meaning that two copies of the defective gene are needed for the condition to appear. The exact genetic mutation or defect that causes GFH is unknown at this time. It is currently unclear whether certain ethnicities or genders are more affected than others.
GFH is characterized by excessive hair growth on the body and enlarged, inflamed gums. Other symptoms may include facial abnormalities, intellectual disabilities, developmental delays, and tooth and skeletal defects.
Patients with GFH may suffer from psychosocial issues associated with excess hair growth. Many try various hair removal techniques with varying levels of success and satisfaction.
Related Terms
Ectodermal dysplasia, GFH, gingival fibromatosis-hypertrichosis, hypertrichosis fibromatosis gingival, hypertrichosis terminalis generalized with gingival hyperplasia, osteochondrodysplasia, werewolf syndrome.
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